منابع مشابه
Resolution of Pump and Leak Components of Sodium and Potassium Ion Transport in Human Erythrocytes
Further support for the pump-leak concept was obtained. Net transport was resolved into pump and leak components with the cardiac glycoside, ouabain. The specificity of ouabain as a pump inhibitor was demonstratcd by its ineffectiveness when the pump was already inhibited by lack of one of the three pump substratcs, sodium ion, potassium ion, or adenosine triphosphate. In the presence of ouabai...
متن کاملResolution of Pump and Leak Components of Sodium and Potassium Ion Transport in Human Erythrocytes
Further support for the pump-leak concept was obtained. Net transport was resolved into pump and leak components with the cardiac glycoside, ouabain. The specificity of ouabain as a pump inhibitor was demonstrated by its ineffectiveness when the pump was already inhibited by lack of one of the three pump substrates, sodium ion, potassium ion, or adenosine triphosphate. In the presence of ouabai...
متن کاملAn Enzymatic Ion Exchange Model for Active Sodium Transport* By
An enzymatic ion exchange model for active sodium transport is described. Kinetic equations relating net flux to time, and to concentration difference across the actively transporting membrane are derived. The second of these equations is tested, using the isolated frog skin in the "short-circuit" apparatus of Ussing. Reasonable lineaxity, as predicted by this equation, is observed. The passive...
متن کاملThe dichotomy of complex I: a sodium ion pump or a proton pump.
C omplex I (NADH quinone oxidoreductase) is the only enzyme of the membrane-bound respiratory chain to remain a ‘‘black box.’’ Atomic resolution structural models are available for three of the four energy-transducing respiratory complexes: the cytochrome bc1 complex, cytochrome oxidase, and the F1 domain of ATP synthase. Detailed mechanisms that integrate these structural models with the resul...
متن کاملThe photochemistry of sodium ion pump rhodopsin observed by watermarked femto- to submillisecond stimulated Raman spectroscopy.
Krokinobacter rhodopsin 2 (KR2) is a recently discovered light-driven Na(+) pump that holds significant promise for application as a neural silencer in optogenetics. KR2 transports Na(+) (in NaCl solution) or H(+) (in larger cation solution, e.g. in CsCl) during its photocycle. Here, we investigate the photochemistry of KR2 with the recently developed watermarked, baseline-free femto- to submil...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2010
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2010.04.097